Trust the defensive line to win
This is a huge test for defensive coordinator Wink Martindale. His instinct will probably be to get cute and send constant blitzes which would be a mistake.
Michigan football has to chose its spots. Kurtis Rourke is a really good college quarterback and he's been hard to confuse this season and is completing 73 percent of his passes.
The defensive line needs to get after him. Mason Graham and Kenneth Grant, along with Derrick Moore and Josaiah Stewart. They also need to be able to defend the run with a few guys in the box as possible. Six would be great but Indiana has been effective running the ball too.
Michigan's defensive line needs to be effective at limiting the run and pressuring the quarterback, otherwise, it's going to be a long day.